The gist of Natural Microdosing

The gist of Natural Microdosing

Making well people better

Very small doses of fresh magic truffles can be safely ingested, without it affecting perception – a practice called Natural Microdosing. Every morning, or optionally every second or third day, you take a measured amount of fresh psilocybin truffles (the standard amount being 1g for an average adult of 70-80kg), as a food supplement. The outstanding advantage of this practice is that it does not impair daily life at all, but gradually manifests beneficial effects, such as:

ability to focus

at the same time, people often have less problems with:

constant stress
mood swings
obsessive behaviour
states of anxiety

The advantage is that perception and everyday life aren’t affected, because Microdosing never comes with immediate effects, but builds up effects over days and weeks.

The whole point of it is to be able to live a better life and to get you there, you don’t want to be taking something that damages you (duh.) or hinders you from going about your business at least as well as you’d normally be able to. It is therefore our conviction that if your microdose makes you unfit for traffic or in fact any complex aspect of daily business, it’s not a microdose.

If you are taking a Natural Microdose, that means:

You can take it daily.
You can do everything you could do without it.
You have no immediate effects, the gradual, long-term benefits will set in after a few days. This goes for both “positive” and “disruptive” effects, even if your dosis makes you super enthusiastic and brimming with energy within minutes – nice! But then it’s not a microdose. Try a bit less the next time, until your dosis is properly sub-perceptual.

Is it safe?

Simply put, yes.

The toxicology of psilocybin fungi is so low that a dosis of about 10-20kg of fresh product is needed in order to cause poisoning.
When done correctly, Microdosing also doesn’t limit everyday functionality, meaning it won’t interfere with your work or play.

There’s reason to be extra careful when you’re also taking medication that influences your serotonin balance, which goes for some antidepressants.

How do magic truffles and mushrooms work?

Microdosing often helps people in various ways; to focus on the task at hand, regulate their mood, reduce stress and obsessive worrying, or even help boost their creativity. 

The compounds responsible for the psychological effects of the Psilocybin mushrooms and truffles are tryptamine alkaloids.


Psilocybin, the most widely known active substance in magic truffles, a so-called prodrug, that is metabolized into psilocin, which in turn stimulates serotonin-receptors in the brain, due to their structural similarity.


Serotonin is one of the most important neurotransmitters, not only in the human body, but in all species with a central nervous system. It’s widely known as a “mood stabilizer” and often thought of as the “happiness hormone”, but in fact is responsible for far more than mood regulation.

High levels of serotonin allow for an active life, promote brain growth and exploration, make us stronger, healthier and more confident. Antidepressants of the SSRI type suppress depressions by slowing down the reabsorption of serotonin, leading to more of it being present in the brain.

Microdosing supplies the brain with psilocybin, which is structurally similar to serotonin, which is why it can activate 5-HT2A receptors in the prefrontal cortex.

Stimulating these receptors causes changes in neurochemistry; causing the release of hormones like BDNF and Glutamate that buffet brain growth and play a key role in learning and memory.

This opens the possibility of new connections being formed in the brain and in part accounts for the increase in creativity and ability to focus. It also facilitates discovering new neurological pathways that remained undiscovered without the activation of the 5-HT2A receptor.

communication of brain regions (a) under usual circumstances and (b) after the intake of a psilocybin dose. The number of signals sent is the same, only the variety of pathways is changed.

Another factor in how the 5-HT2A receptor alters brain function are its dampening effect on the Default Mode Network. This network is responsible for what we spend our time with when we’re not focused on any particular intellectual task, as for example when we’re driving, resting or doing chores. The fact that our mood improves is also related to spending less time in self-critical daydreams and ruminations as the DMN shifts down a gear.

In conditions such as depression, there’s often an overly active default mode network involved, causing excessive involvement in worries about the self.